Transport and inhibition mechanisms of the human noradrenaline transporter
1 August 2024Nature, Published online: 31 July 2024; doi:10.1038/s41586-024-07638-z
Cryo-electron microscopy structures of the noradrenaline transporter (NET) reveal binding modes of adrenaline, coordination of sodium and chloride ion binding and the binding sites and mechanisms of inhibition by conotoxin, bupropion and ziprasidone.