Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09718-0

Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lunapark protein and is modulated by nutrient status.