Fasting boosts breast cancer therapy efficacy via glucocorticoid activation

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09869-0

Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting to reduce harmful effects.