Modular in vivo antibody–ADC click to reverse drug resistance in tumours
16 July 2026Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10789-w
In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.