De novo design of GPCR exoframe modulators
17 February 2026Nature, Published online: 16 February 2026; doi:10.1038/s41586-025-09957-1
De novo designed proteins that target the transmembrane domain of G-protein-coupled receptors, created using iterative structural predictions, are able to act as agonist-positive, negative or biased allosteric modulators of downstream activity.