Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09503-z

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.