Stepwise activation of a metabotropic glutamate receptor

Nature, Published online: 17 April 2024; doi:10.1038/s41586-024-07327-x

We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.