Mechanical activation opens a lipid-lined pore in OSCA ion channels

Nature, Published online: 03 April 2024; doi:10.1038/s41586-024-07256-9

The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding understanding of channel-mediated mechanotransduction and pore formation, with implications for two protein families.